Effect of Spironolactone on Diastolic Function and Exercise Capacity in Patients WithHeartFailureWithPreservedEjectionFraction

HEART FAILURE (HF) WITH preserved ejection fraction (EF) accounts for more than 50% of the total HF population. Community-based cohort studies have shown that mortality rates are similar in HF with preserved EF compared with HF with reduced EF, but data from large clinical trials point toward a better outcome in HF with preserved EF. This may indicate that comorbidities that are typically excluded in trials may contribute to the poor prognosis in HF with preserved EF. Left ventricular diastolic dysfunction and adverse cardiac remodeling are considered major Importance Diastolic heart failure (ie, heart failure with preserved ejection fraction) is a common condition without established therapy, and aldosterone stimulation may contribute to its progression.